HubSpot's KB: connect Microsoft 365 GCC High to send one-to-one and sequence emails and log them. HubSpot notes it is not CMMC or FedRAMP compliant; your legal team should advise.
1. In HubSpot
The relevant screen in my demo portal.
Connect email account (1), Add email alias (2), and Manage email signatures (3).
2. Worth knowing
Install the Office 365 add-in for sales tools in the inbox.