Short answer
HubSpot's re-engagement guide uses an events-based filter: Marketing emails | [your email] | Email was sent to contact but they didn't click on a link. Use the same approach for non-openers. By default, HubSpot doesn't send to unengaged contacts, meaning recipients who haven't opened your last 11 marketing emails.
1. Recipients
Send to and Don't send to in my demo portal.
2. Go easy
Resending to people who ignored the first email adds to graymail. See unengaged contacts.